Chemoprevention strategies among Kenyan primary school children

Reference Number: 
Chemosch012023
Location: 
Nairobi
Country: 
Kenya
Supervisor: 
TBC
Description: 

The highest malaria mortality and morbidity burden in sub-Saharan Africa remains concentrated in children aged less than five years. However, there is a growing recognition that significant untreated asymptomatic infection, anaemia and consequential burdens are borne by children aged 5-15 years – the school aged child (SAC). Recent evidence further suggests that this age group contribute a large fraction of gametocyte infectious reservoir in communities and are often less well protected with long-lasting insecticide treated nets. 

The Global Malaria Programme (GMP) of the World Health Organization (WHO) has recently revised a range of chemoprevention guidelines to include the SAC, referred to as Intermittent Presumptive Treatment of school children (IPTsc).  A conditional recommendation has been provided “School-aged children living in malaria-endemic settings with moderate to high perennial or seasonal transmission can be given a full therapeutic course of antimalarial medicine at predetermined times as chemoprevention to reduce disease burden

This recommendation was based on evidence from a limited number of trials that the burden of malaria can be reduced but that the benefits of IPTsc may vary across the school attending age range, transmission intensity setting, seasonality of transmission and drug half-lives. It was also recognised that IPTsc is likely to be most efficient if combined with other existing school-based health programmes such as deworming.

This PhD project will explore this further and especially conceptualize a suitable framework for understanding the impact of targeted chemoprevention strategies among primary school children in Kenya.

 

ELIGIBILITY

Applicants must have attained at least an upper 2nd class degree or its equivalent in a related field and a masters’ degree in Epidemiology, Public Health, Biostatistics, Geospatial engineering or another related field. Applicants must also have experience in research.

For undergraduate degrees that are not classified, ensure your average score through the four/three years is above 60 (GPA above 3.3). Provide a certified proof of the same from your University.

 

SELECTION

Studentships are awarded competitively through shortlisting of online applications and subsequent face to face (or online) interviews.

 

STARTING DATE

Studentships will start as soon as possible.

 

APPLICATION DEADLINE: 11 February 2023

FURTHER INFORMATION: Please direct all other concerns/questions to Dr. Dorcas Mbuvi [dmbuvi@kemri-wellcome.org].